OX40:OX40L axis: emerging targets for improving poxvirus-based CD8+ T-cell vaccines against respiratory viruses
نویسندگان
چکیده
منابع مشابه
Targeting OX40 promotes lung-resident memory CD8 T cell populations that protect against respiratory poxvirus infection.
One goal of vaccination is to promote development of mucosal effector cells that can immediately respond to peripheral infection. This is especially important for protection against viruses that enter the host through the respiratory tract. We show that targeting the OX40 costimulatory receptor (CD134) strongly promotes mucosal memory in the CD8 T cell compartment. Systemic injection of an agon...
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ژورنال
عنوان ژورنال: Immunological Reviews
سال: 2011
ISSN: 0105-2896
DOI: 10.1111/j.1600-065x.2011.01062.x